Theories and Mechanism of dissolution
In order for an active pharmaceutical ingredient to be bioavailable , it has to be dissolved. Thus, solubility and dissolution measurements are necessary requirements to estimate the drugs bioavailability: . In theory, the intrinsic dissolution rate (IDR) is proportional to the solubility of the compound – i.e. in many cases a very good estimate of IDR can be obtained directly from a solubility measurement: Low solubility = low IDR and vice versa. It also implies that the dissolution rate is proportional to the solubility (but here the particle size/the surface area of the particles should also be taken into account). However, in some cases the liberation af molecules from the surface into water is not ideal – and the dissolution rate will be lower or higher than theoretically calculated. Thus, in order to determine whether your compound behaves ”ideal”, a measurement of IDR is neccessary. Click here for learning more about theories and mechanism of dissolution in