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Showing posts from December, 2016

Theories and Mechanism of dissolution

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In order for an active pharmaceutical ingredient to be  bioavailable , it has to be dissolved. Thus, solubility and dissolution measurements are  necessary requirements to estimate the drugs bioavailability: . In theory, the  intrinsic dissolution rate (IDR)  is proportional to the solubility of the compound – i.e. in many cases a very good estimate of IDR can be obtained directly from a solubility measurement: Low solubility = low IDR and vice versa.  It also implies that the  dissolution rate  is proportional to the solubility (but here the particle size/the surface area of the particles should also be taken into account). However, in some cases the liberation af molecules from the surface into water is not ideal – and the dissolution rate will be lower or higher than theoretically calculated. Thus, in order to determine whether your compound behaves ”ideal”, a measurement of IDR is neccessary. Click here for learning more about theories and mechanism of dissolution in

Clinical Research Associate: Career option to pharmacist

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The field of clinical research offers a rewarding and dynamic career path for those interested in contributing to the development of new medical treatments and therapies. Clinical Research Associates (CRAs) play a pivotal role in this industry, ensuring that clinical trials are conducted safely, ethically, and in accordance with regulatory standards. In this blog post, we will explore the career path of a Clinical Research Associate and the qualifications required to embark on this exciting journey. The Role of a Clinical Research Associate (CRA): Clinical Research Associates are responsible for monitoring and managing clinical trials, ensuring that they adhere to protocols and regulatory requirements. They collaborate with research teams, healthcare professionals, and sponsors to collect and analyze data, making sure that trials progress smoothly. CRAs play a crucial part in bringing innovative medical treatments to market. Qualifications Required to Become a Clinical Researc