Theories and Mechanism of dissolution

In order for an active pharmaceutical ingredient to be bioavailable, it has to be dissolved. Thus, solubility and dissolution measurements are  necessary requirements to estimate the drugs bioavailability:
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  • In theory, the intrinsic dissolution rate (IDR) is proportional to the solubility of the compound – i.e. in many cases a very good estimate of IDR can be obtained directly from a solubility measurement: Low solubility = low IDR and vice versa.
  •  It also implies that the dissolution rate is proportional to the solubility (but here the particle size/the surface area of the particles should also be taken into account).
  • However, in some cases the liberation af molecules from the surface into water is not ideal – and the dissolution rate will be lower or higher than theoretically calculated. Thus, in order to determine whether your compound behaves ”ideal”, a measurement of IDR is neccessary.

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